Large, regulated rivers of the Northwest anchor biodiversity, Tribal lifeways, and regional economies. Yet hydropower, land-use change, and climate stressors have reshaped flow and thermal regimes, sediment and nutrient dynamics, floodplain connectivity, and food webs. Building resilience in these systems requires cross-disciplinary science and sustained collaboration among communities, Tribes, agencies, and universities. This opening presentation frames the special session by highlighting the monitoring, management, and restoration approaches needed to support resilience in large rivers. We invite practitioners and scientists to share research and programs that directly inform resilient watershed management, including work linking community-based monitoring and integrative indicators (e.g., whole-river metabolism, production, food-web quality, thermal refugia, eDNA/bioassessment, and sensor and remote networks) to management actions, including Indigenous-informed decisions. We begin the session with examples from the Kootenai River collaborative group to illustrate how integrative science and partnership-based approaches can connect ecosystem processes to restoration effectiveness in floodplains, side channels, and riparian areas, and to provide a common context for the talks that follow.