I examine changes in water color along the Klamath River from 2016 to the present using a combination of satellite-based remote sensing (Sentinel-2) and in situ water gauging. The Klamath River has nominally blue water in flows from the Trinity, Salmon, Shasta, and Scott Rivers that alter the water's composition and color. In addition, storm runoff also carries significant sediment loads, giving the water a brownish or reddish hue, particularly in the region affected by the 2022 McKinney fire. Lastly, significant phytoplankton populations from the reservoirs above the Keno Dam color the water green. We develop spectral fingerprints for these different source waters based on above-water hyperspectral measurements and use these ground-based measurements to aid in identifying and tracking sediment and other water constituent transport in the Klamath River from Keno Dam to its entrance into the Pacific Ocean at Requa. A spatially dense view of the river is presented with imagery from the Sentinel-2 satellite (nominally 10-meter resolution every 2-3 days), and temporally dense water-quality data (every 15 minutes) is also available from a few sites thanks to the extensive monitoring efforts of the Karuk and Yurok Tribes, as well as from the USGS. An initial attempt is described to track the journey of different source waters and sediments down the Klamath River by combining remote sensing and in situ gauging.