Successful management of biological invasions requires the virtuous cycle of research innovation, policy, and commercialization to spin much faster. During the 42 years of my research career on invasive species, multiple research innovations from many researchers have produced a sophisticated policy-relevant understanding of all stages of biological invasions, and many technological innovations relevant to species management. However, policy innovation to move research innovations along the technology readiness scale into the marketplace has often stalled. Investments to develop practical tools to identify, interdict, eradicate, or slow-the-spread of species have lagged well behind research innovation, and remain grossly insufficient to support species management at the frequency and geographic scales required. Thus the toolbox for managing biological invasions remains poorly stocked. This is especially true for freshwater and marine ecosystems. Using environmental DNA (eDNA) and other recent technological advances, I will describe policy changes that could quickly produce great societal benefit via effective and efficient biosecurity measures, including early detection and rapid responses.